2-Hydroxy estrone

CAS: 362-06-1

Ref. 3D-FH23994

Product Information

• Name: 2-Hydroxy estrone
• Synonyms: 2,3-Dihydroxyestra-1,3,5(10)-trien-17-oneCatecholestrone, 2,3-Dihydroxyestra-1(10),2,4-Trien-17-One, 2,3-Dihydroxyestra-1,3,5(10)-trien-17-one, Catecholestrone, Ccris 9276, Estra-1,3,5(1)-trien-17-one, 2,3-dihydroxy-, Estra-1,3,5(10)-trien-17-one, 2,3-dihydroxy-

Description

2-Hydroxy estrone is a metabolite of estradiol. It has been shown to be involved in the development of breast cancer and may be a biomarker for the disease. 2-Hydroxy estrone has been found to have genotoxic effects in experimental models and may cause DNA damage. It is also thought to play a role in regulating body weight, reproductive function, mood, and cognition. 2-Hydroxy estrone is an estrogen precursor that binds catechol-o-methyltransferase (COMT) and thereby inhibits COMT activity. This leads to increased levels of dopamine which contributes to breast cancer development. Experimental models have shown that 2-hydroxy estrone can induce tumours in mice by binding to estrogen receptors and stimulating cell division.

• Brand: Biosynth

Chemical properties

• Molecular weight: 286.37 g/mol
• Formula: C₁₈H₂₂O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1
• InChI key: InChIKey=SWINWPBPEKHUOD-JPVZDGGYSA-N
• SMILES: C[C@]12CC[C@@H]3c4cc(O)c(O)cc4CC[C@H]3[C@@H]1CCC2=O