4-Hydroxy estrone
CAS: 3131-23-5
Ref. 3D-FH23995
| 1mg | To inquire | ||
| 2mg | To inquire | ||
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire |
Product Information
- 1,3,5(10)-Estratriene-3,4-diol-17-one3,4-Dihydroxy-1,3,5(10)-estratrien-17-one
4-Hydroxy estrone is a metabolite of estrone. It has been shown to have genotoxic activity, which is thought to be due to its ability to form DNA adducts. 4-Hydroxy estrone has also been found to cause cancer in rat liver microsomes and body mass index in female rats. 4-Hydroxy estrone can be found in the environment as a result of wastewater treatment, where it reacts with triclosan and other compounds. 4-Hydroxy estrone has been shown to inhibit the activity of enzymes such as cytochrome P450 and aromatase that are involved in estrogen metabolism. Tumour necrosis factor-α (TNF-α) stimulates the production of this compound, which is thought to play an important role in the development of obesity-related cancers.
Chemical properties
Technical inquiry about: 3D-FH23995 4-Hydroxy estrone
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