6β-Hydroxy prednisolone

Ref. 3D-FH24098

Product Information

• Name: 6β-Hydroxy prednisolone
• Synonyms: (6β,11β)-6,11,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
• Brand: Biosynth
• Description: 6b-Hydroxy prednisolone is a metabolite of prednisolone. The metabolism of prednisolone to 6b-hydroxy prednisolone is catalyzed by the enzyme CYP3A4, which results in the formation of 6β-hydroxyprednisolone and a hydrogen peroxide that reacts with catalase to form water and oxygen. The conversion is dependent on the concentration of galactose, as it provides substrate for CYP3A4. If cyclosporine or other drugs are taken concurrently, they may inhibit the metabolism of 6b-hydroxy prednisolone. The kinetics of 6β-hydroxyprednisolone have been investigated in tissues and plasma samples, and it has been shown that this metabolite has a short half-life in both tissues and plasma samples. This drug can be analysed using chromatography, but endogenous substances such as cortisol can interfere with the process.

Chemical properties

• Molecular weight: 376.44 g/mol
• Formula: C₂₁H₂₈O₆
• Purity: Min. 95%
• Color/Form: Light (Or Pale) Yellow Solid