(E)-3-Hydroxy tamoxifen

CAS: 82413-20-5

Ref. 3D-FH24130

Product Information

• Name: (E)-3-Hydroxy tamoxifen
• Synonyms: 3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenolDroloxifeneE-Droloxifene, (1E)-1-[4'-(2-Dimethylaminoethoxy)phenyl]-1-(3-hydroxyphenyl)-2-phenylbut-1-ene, (E)-1-[4'-(2-Dimethylaminoethoxy)phenyl]-1-(3-hydroxyphenyl)-2-phenylbut-1-ene, (E)-3-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol, (E)-alpha-(p-(2-(Dimethylamino)ethoxy)phenyl)-alpha'-ethyl-3-stilbenol, (E)-alpha-(para-(2-(Dimethylamino)ethoxy)phenyl)-alpha'-ethyl-3-stilbenol (IUPAC), 2YR& UYR CQ& R DO2N1& 1 & & E Form, 3-Hydroxytamoxifen, 3-[(1E)-1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenyl-1-buten-1-yl]phenol, 3-[(1E)-1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol, 3-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol, E-Droloxifene, K 060, K 060E, K 21.060E, Phenol, 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-, Phenol, 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, Phenol, 3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (E)-

Description

(E)-3-Hydroxy tamoxifen is a synthetic drug that has been used for the treatment of vaginal atrophy and breast cancer. (E)-3-Hydroxy tamoxifen is a prodrug that is hydrolyzed in vivo to its active form, 4-hydroxytamoxifen. It has been shown to be an effective anti-cancer compound that binds to calcium ions and inhibits the production of IGF-I in rat liver microsomes and carcinoma cell lines. The metabolite of (E)-3-hydroxy tamoxifen, endoxifen, is also a potent estrogen antagonist and has been shown to prevent bowel disease in rats. (E)-3-Hydroxy tamoxifen has also been shown to inhibit the growth of breast cancer cells with oestrogen receptors.

• Brand: Biosynth

Chemical properties

• Molecular weight: 387.51 g/mol
• Formula: C₂₆H₂₉NO₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C26H29NO2/c1-4-25(20-9-6-5-7-10-20)26(22-11-8-12-23(28)19-22)21-13-15-24(16-14-21)29-18-17-27(2)3/h5-16,19,28H,4,17-18H2,1-3H3/b26-25+
• InChI key: InChIKey=ZQZFYGIXNQKOAV-OCEACIFDSA-N
• SMILES: CC/C(=C(/c1ccc(OCCN(C)C)cc1)c1cccc(O)c1)c1ccccc1