DL-4-Hydroxy-2-ketoglutarate dilithium salt

CAS: 1187-99-1

Ref. 3D-FH24198

Product Information

• Name: DL-4-Hydroxy-2-ketoglutarate dilithium salt
• Synonyms: 2-Hydroxy-4-oxopentanedioic acid, 2-Keto-4-Hydroxyglutarate, 4-Hydroxy-2-ketoglutaric acid, 4-Hydroxy-2-oxoglutaric acid, <span class="text-smallcaps">DL</span>-2-Oxo-4-hydroxyglutarate, <span class="text-smallcaps">DL</span>-2-keto-4-Hydroxyglutaric acid, <span class="text-smallcaps">DL</span>-4-Hydroxy-2-ketoglutaric acid, Glutaric acid, 2-hydroxy-4-oxo-, Pentanedioic acid, 2-hydroxy-4-oxo-, γ-Hydroxy-α-ketoglutaric acid

Description

DL-4-Hydroxy-2-ketoglutarate dilithium salt (DL4KG) is a lysine analogue that is used as a substrate for the enzyme aldolase. DL4KG has a hydroxyl group, which can react with the amino group of lysine residues on proteins to produce an unstable intermediate. This process eventually leads to the production of glutamate and glyceraldehyde 3-phosphate, which are needed in the synthesis of ATP. DL4KG has been shown to be an inhibitor of bacterial enzymes such as glutamate dehydrogenase, which catalyzes the conversion of L-glutamic acid to L-glutamine. Inhibition by DL4KG has been demonstrated in vitro at concentrations between 2 and 10 mM.

• Brand: Biosynth

Chemical properties

• Molecular weight: 173.96 g/mol
• Formula: C₅H₄O₆Li₂
• Purity: 90%Min
• Color/Form: White to off-white solid.