3-Hydroxyglutaric acid dimethyl ester

CAS: 7250-55-7

Ref. 3D-FH24357

Product Information

• Name: 3-Hydroxyglutaric acid dimethyl ester
• Synonyms: 3-Hydroxy-pentanedioic acid dimethyl esterDimethyl 3-hydroxyglutarateNSC 30047, 1,5-Dimethyl 3-hydroxypentanedioate, 3-Hydroxyglutaric Acid Dimethyl Ester, 3-Hydroxypentanedioic acid dimethyl ester, Dimethyl 3-hydroxypentanedioate, Dimethyl β-hydroxyglutarate, Dimethyl-3-hydroxyglutarat, Glutaric acid, 3-hydroxy-, dimethyl ester, NSC 30047, Nistc7250557, Pentanedioic acid, 3-hydroxy-, 1,5-dimethyl ester, Pentanedioic acid, 3-hydroxy-, dimethyl ester

Description

3-Hydroxyglutaric acid dimethyl ester (3HGDE) is a synthetic compound that is used in the synthesis of enantiopure compounds. It is synthesized through a borohydride reduction of 3-hydroxybutanoic acid, followed by the desymmetrization of the resulting alcohol with sodium methoxide. This process can be carried out in two ways: kinetic or immobilization. The first method involves the use of a catalyst such as acetic acid and ammonium chloride to reduce the reaction time, while immobilization uses an enzyme such as lipase to catalyze. 3HGDE has been shown to be a good substrate for monoethyl hydrogenation, which can be used to produce hydroxybutanoate and l-tartaric acid.

• Brand: Biosynth

Chemical properties

• Molecular weight: 176.17 g/mol
• Formula: C₇H₁₂O₅
• Purity: Min. 95%
• InChI: InChI=1S/C7H12O5/c1-11-6(9)3-5(8)4-7(10)12-2/h5,8H,3-4H2,1-2H3
• InChI key: InChIKey=CUPGMRSSZADEIW-UHFFFAOYSA-N
• SMILES: COC(=O)CC(O)CC(=O)OC