(R)-5-Hydroxymethyl tolterodine

CAS: 207679-81-0

Ref. 3D-FH24399

Product Information

• Name: (R)-5-Hydroxymethyl tolterodine
• Synonyms: 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol5-Hydroxymethyl tolterodine, (+)-N,N-Diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropylamine, 2-[(1R)-3-[Di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol, 3-[(1R)-3-[Bis(1-Methylethyl)Amino]-1-Phenylpropyl]-4-Hydroxy-Benzenemethanol, 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol, 5-Hydroxymethyltolterodine, Benzenemethanol, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-, Desfesoterodine, Pnu 200577, R-(+)-2(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol, Spm 7605

Description

(R)-5-Hydroxymethyl tolterodine is a prodrug that is metabolized by cytochrome P450 3A4 (CYP3A4) in the liver to its active form, tolterodine. This drug can be used as an alternative for gabapentin in the treatment of detrusor muscle overactivity associated with neurogenic bladder dysfunction. The pharmacokinetic properties of (R)-5-hydroxymethyl tolterodine are similar to those of gabapentin, including the elimination half-life and volume of distribution. However, unlike gabapentin, which has been shown to increase the glomerular filtration rate (GFR) and renal blood flow, there is no evidence that this drug has any effect on GFR or renal blood flow. There is also no evidence that (R)-5-hydroxymethyl tolterodine causes any symptoms that may be attributed to

• Brand: Biosynth

Chemical properties

• Molecular weight: 341.49 g/mol
• Formula: C₂₂H₃₁NO₂
• Purity: Min. 98 Area-%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C22H31NO2/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3/t20-/m1/s1
• InChI key: InChIKey=DUXZAXCGJSBGDW-HXUWFJFHSA-N
• SMILES: CC(C)N(CC[C@H](c1ccccc1)c1cc(CO)ccc1O)C(C)C