(2E)-1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one

CAS: 888-12-0

Ref. 3D-FH24462

Product Information

• Name: (2E)-1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one
• Synonyms: (E)-2'-Hydroxy-chalcone(E)-o-Hydroxyphenyl styryl ketoneNSC 170284
• Brand: Biosynth
• Description: The 2-hydroxyphenyl-3-phenylpropenal (HPPA) is a fatty acid with a hydroxyl group. It has been shown to have anti-inflammatory properties and inhibit the production of TNF-α in mice. HPPA is synthesized by the oxidation of oleic acid, which can be catalyzed by a number of different enzymes such as lipoxygenases, cyclooxygenases, or cytochrome P450s. The synthesis can also be inhibited by other substances such as dibromides or tnf-α. HPPA also has potent inhibitory activity against transcription polymerase chain reaction and protein synthesis. This inhibition is due to its carbonyl group that reacts with the intramolecular hydrogen on the enzyme's active site. The reaction mechanism for this inhibition is similar to that of propranolol, another drug used for treatment of inflammatory diseases.

Chemical properties

• Molecular weight: 224.25 g/mol
• Formula: C₁₅H₁₂O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+
• InChI key: InChIKey=AETKQQBRKSELEL-ZHACJKMWSA-N
• SMILES: O=C(/C=C/c1ccccc1)c1ccccc1O