5-Hydroxyquinolin-2(1H)-one

CAS: 31570-97-5

Ref. 3D-FH24497

Product Information

• Name: 5-Hydroxyquinolin-2(1H)-one
• Synonyms: 5-Hydroxy-2(1H)-quinolone5-Hydroxycarbostyril5-Hydroxyquinolin-2(1H)-one
• Brand: Biosynth
• Description: 5-Hydroxyquinolin-2(1H)-one is a chalcone that can be synthesized from 2,5-dihydroxybenzaldehyde and quinoline. It is a bacteriostatic agent that inhibits bacterial growth by binding to the 50S ribosomal subunit, blocking the formation of an antibiotic-substrate complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 5-Hydroxyquinolin-2(1H)-one has shown activity against methicillin resistant Staphylococcus aureus (MRSA) and methicillin resistant Enterococcus faecium. 5-Hydroxyquinolin-2(1H)-one also represses the expression of DNA topoisomerase II genes, which may be associated with its inhibitory effects on bacterial growth.

Chemical properties

• Molecular weight: 161.16 g/mol
• Formula: C₉H₇NO₂
• Purity: Min. 95%
• InChI: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-5,11H,(H,10,12)
• InChI key: InChIKey=XOXGLLQTNQBDKL-UHFFFAOYSA-N
• SMILES: O=c1ccc2c(O)cccc2[nH]1