4'-Hydroxychalcone

CAS: 2657-25-2

Ref. 3D-FH36595

Product Information

• Name: 4'-Hydroxychalcone
• Synonyms: (2E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one, 1-(4-Hydroxyphenyl)-3-Phenylprop-2-En-1-One, 1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one, 1-(4-Hydroxyphenyl)-3-phenylpropenone, 2-Propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl-, 4-Hydroxyphenyl styryl ketone, Benzylidene-(4-hydroxyacetophenone), Chalcone, 4′-hydroxy-, NSC 242264, p-Cinnamoylphenol
• CAS: 2657-25-2

Description

4'-Hydroxychalcone is a compound that has shown to be an insulin resistance suppressant. It reduces the activity of recombinant cytochrome P450 enzymes and blocks hydroxy group metabolism, which leads to a decrease in ATP levels. This molecule also has biological properties as it can inhibit the expression of β-catenin and induce apoptosis in cancer cells. 4'-Hydroxychalcone has been found to inhibit the transfer mechanism of phosphatidylinositol 3-kinase (PTP1B) and is able to bind with the protein marker p62/SQSTM1.
4'-Hydroxychalcone is a potent inhibitor for PTP1B, which is a negative regulator for insulin signaling pathways. In addition, 4'-hydroxychalcone can bind with p62/SQSTM1, which is a marker for autophagy proteins. These properties have been shown to have anti-cancer effects on multiple cancer types including

• Brand: Biosynth

Chemical properties

• Molecular weight: 224.25 g/mol
• Formula: C₁₅H₁₂O₂
• Color/Form: Powder
• InChI: InChI=1S/C15H12O2/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-11,16H/b11-6+
• InChI key: InChIKey=UAHGNXFYLAJDIN-IZZDOVSWSA-N
• SMILES: O=C(/C=C/c1ccccc1)c1ccc(O)cc1