1-Hydroxypyridine-2-thione zinc

CAS: 13463-41-7

Ref. 3D-FH40903

Product Information

• Name: 1-Hydroxypyridine-2-thione zinc
• Brand: Biosynth
• Description: Zinc pyrithione is a chemical compound that can be used as an antifungal agent. It has been shown to have genotoxic activity in vitro and in vivo. Zinc pyrithione binds to the surface of the fungal cell wall and inhibits the synthesis of ergosterol, a component of the fungal cell membrane. This binding prevents the formation of an ergosterol-zinc complex with cytochrome P450 enzymes, which are required for sterol biosynthesis, leading to inhibition of energy metabolism. The model system for zinc pyrithione is a mixture of 1-hydroxypyridine-2-thione (1HP) and zinc ions in water. Some studies have shown that zinc pyrithione can cause long-term toxicity, including glycol ether toxicity, when applied topically on hair or skin. Acute toxicities may include skin irritation or contact dermatitis from shampoos containing this substance.

Chemical properties

• Molecular weight: 317.69 g/mol
• Formula: C₁₀H₈N₂O₂S₂Zn
• Purity: Min. 95%
• Color/Form: White/Off-White Solid