4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
CAS: 91526-18-0
Ref. 3D-FH43247
| 1g | 185.00 € | ||
| 2g | 310.00 € | ||
| 5g | 597.00 € | ||
| 10g | 1,042.00 € | ||
| 500mg | 136.00 € |
Product Information
- Dmdo-Oh
- 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one(DMDO-OH)
- 4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one
- 4-Methyl-5-hydroxymethyl-2-oxo-1,3-dioxol-4-ene
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug. The pro-drug helps to increase the bio-availability of the active drug which is generated in vivo by a base catalysed decomposition process that destroys the 1,3-dioxol-2-one ring. A high-profile example of this is the hypertension drug Alizsartan medoxomil. 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl)methyloxyoxayl chloride which provides for an alternative approach to introduce the (oxodioxolenyl)methyl carbamate group.
Chemical properties
Technical inquiry about: 3D-FH43247 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
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