4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
CAS:
Ref. 3D-FH43247
2g
291.00€
5g
560.00€
10g
973.00€
25g
2,030.00€
10kg
8,104.00€
Product Information
Name:4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Brand:Biosynth
Description:4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug. The pro-drug helps to increase the bio-availability of the active drug which is generated in vivo by a base catalysed decomposition process that destroys the 1,3-dioxol-2-one ring. A high-profile example of this is the hypertension drug Alizsartan medoxomil. 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl)methyloxyoxayl chloride which provides for an alternative approach to introduce the (oxodioxolenyl)methyl carbamate group.
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Chemical properties
Molecular weight:130.1 g/mol
Formula:C5H6O4
Purity:Min. 95%
Color/Form:Colorless Clear Liquid
Technical inquiry about: 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
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