(S)-5-Hydroxypiperidin-2-one
CAS: 24211-54-9
Ref. 3D-FH59583
1g | Discontinued | ||
2g | Discontinued | ||
5g | Discontinued | ||
250mg | Discontinued | ||
500mg | Discontinued |
Product Information
- 2-Piperidinone,5-hydroxy-, (S)-
- 2-Piperidone, 5-hydroxy-, stereoisomer (8CI)
- (S)-5-Hydroxy-2-piperidinone
(S)-5-Hydroxypiperidin-2-one is a chiral compound that is used in the synthesis of tofacitinib. It can be obtained by nitroaldol reaction of L-tyrosine with dimethylzinc, which yields the racemic mixture of (R)- and (S)-isomers. The stereoselective synthesis of (S) 5-hydroxypiperidin-2-one also requires the use of chiral reagents such as enantioselective catalysts or diastereoselective reagents. This compound has been shown to have anti-inflammatory properties in an animal model.