7-Hydroxy-5-methoxyflavanone

CAS: 36052-37-6

Ref. 3D-FH65556

Product Information

• Name: 7-Hydroxy-5-methoxyflavanone
• Synonyms: Alpinetin, (2S)-2,3-Dihydro-7-hydroxy-5-methoxy-2-phenyl-4H-1-benzopyran-4-one, (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one, (2S)-7-hydroxy-5-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one, (S)-7-Hydroxy-5-methoxy-2-phenylchroman-4-one, 2,3-Dihydro-7-hydroxy-5-methoxy-2-phenyl-4H-1-benzopyran-4-one, 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-5-methoxy-2-phenyl-, (2S)-, 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-5-methoxy-2-phenyl-, (S)-, 5-Methoxy-7-hydroxyflavanone, 5-O-Methylpinocembrin, 7-hydroxy-5-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one, Flavanone, 7-hydroxy-5-methoxy-

Description

7-Hydroxy-5-methoxyflavanone is a flavonoid found in alpinia, an herbal Chinese medicine. It has been shown to have anticancer activity by inducing apoptosis in cancer cells. 7-Hydroxy-5-methoxyflavanone also inhibits the expression of Bcl-2 protein, which is found in the mitochondria and blocks apoptosis. This compound also induces cell death in PC12 cells through DNA damage and inhibition of protein synthesis. This effect can be enhanced with the use of chemotherapeutic drugs such as alpinetin or ethyl ether. These compounds have been shown to induce ischemic preconditioning, a protective response to injury that can be induced by brief periods of ischemia followed by reperfusion. 7-Hydroxy-5-methoxyflavanone has been shown to protect against kidney injury caused by cisplatin treatment and may be useful for preventing renal failure in cis

• Brand: Biosynth

Chemical properties

• Molecular weight: 270.28 g/mol
• Formula: C₁₆H₁₄O₄
• Purity: Min. 95 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C16H14O4/c1-19-14-7-11(17)8-15-16(14)12(18)9-13(20-15)10-5-3-2-4-6-10/h2-8,13,17H,9H2,1H3/t13-/m0/s1
• InChI key: InChIKey=QQQCWVDPMPFUGF-ZDUSSCGKSA-N
• SMILES: COc1cc(O)cc2c1C(=O)C[C@@H](c1ccccc1)O2