2'-Hydroxy-4,4',6'-trimethoxychalcone

CAS: 3420-72-2

Ref. 3D-FH67763

Product Information

• Name: 2'-Hydroxy-4,4',6'-trimethoxychalcone
• Synonyms: Flavokawain A, (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, 1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one, 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-, 2′-Hydroxy-4,4′,6′-trimethoxychalcone, 4-Methoxybenzylidene(4,6-dimethoxy-2-hydroxyacetophenone), Chalcone, 2′-hydroxy-4,4′,6′-trimethoxy-, NSC 37445

Description

2'-Hydroxy-4,4',6'-trimethoxychalcone is a flavokawain derivative that inhibits the protein p-glycoprotein (P-gp). This compound has been shown to inhibit tumor growth and induce apoptosis in vitro. It also displays antiinflammatory activity by inhibiting the activation of NF-κB pathway. 2'-Hydroxy-4,4',6'-trimethoxychalcone also exhibits minimal toxicity in animal models and has been found to be effective against melanoma cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 314.33 g/mol
• Formula: C₁₈H₁₈O₅
• Purity: Min. 95%
• Color/Form: Yellow Powder
• InChI: InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+
• InChI key: InChIKey=CGIBCVBDFUTMPT-RMKNXTFCSA-N
• SMILES: COc1ccc(/C=C/C(=O)c2c(O)cc(OC)cc2OC)cc1