4-(Hydroxymethyl)benzoic acid methyl ester

CAS: 6908-41-4

Ref. 3D-FH70263

Product Information

• Name: 4-(Hydroxymethyl)benzoic acid methyl ester
• Synonyms: Methyl 4-(Hydroxymethyl)benzoate4-Carbomethoxybenzyl alcohol, 4-(Carbomethoxy)benzyl alcohol, 4-(Methoxycarbonyl)benzyl alcohol, 4-Carbomethoxybenzyl alcohol, 4-Hydroxymethylbenzoic acid methyl ester, Benzoic acid, 4-(hydroxymethyl)-, methyl ester, Methyl p-(hydroxymethyl)benzoate, p-(Methoxycarbonyl)benzyl alcohol, p-Toluic acid, α-hydroxy-, methyl ester, Methyl (4-hydroxymethyl)benzoate, Methyl 4-(hydroxymethyl)benzoate, Methyl 4-(hydroxymethyl)benzoate

Description

4-(Hydroxymethyl)benzoic acid methyl ester is a quinazolinone that has been used as an anticancer drug. It is synthesized by cross-coupling of 4-hydroxymethylbenzoic acid and methyl iodide with a cobaltic catalyst, followed by dehydrogenation. The synthesis can also be achieved using a molybdenum catalyst, leading to the same product. 4-(Hydroxymethyl)benzoic acid methyl ester is an efficient method for the synthesis of this compound and has shown anti-cancer activity in animal models. It inhibits serine proteases, including matrix metalloproteinases (MMPs) and cathepsin B, which are enzymes involved in cancer cell invasion and metastasis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 166.17 g/mol
• Formula: C₉H₁₀O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C9H10O3/c1-12-9(11)8-4-2-7(6-10)3-5-8/h2-5,10H,6H2,1H3
• InChI key: InChIKey=VBWFYEFYHJRJER-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc(CO)cc1