3-Hydroxybenzamide

CAS: 618-49-5

Ref. 3D-FH70985

Product Information

• Name: 3-Hydroxybenzamide
• Synonyms: 3-Hydroxy-Benzoic Acid,Amide, 3-Hydroxy-benzamide, 3-Hydroxybenzenecarboxamide, 3-Hydroxyphenylformamide, Benzamide, 3-Hydroxy-, Benzamide, m-hydroxy-, NSC 379289, Sr 4267, m-Hydroxybenzamide

Description

3-Hydroxybenzamide is a potent inhibitor of the enzyme synthetase and has been shown to inhibit the synthesis of adenosine diphosphate (ADP) ribose. It has been shown to have potent inhibitory activity against the enzyme in both solid and liquid phases. 3-Hydroxybenzamide binds to the carbonyl group of ADP ribose, which prevents it from binding to ATP. This inhibition of the synthesis of nucleotides limits cell proliferation by preventing DNA replication and protein synthesis. 3-Hydroxybenzamide has also been shown to inhibit the growth of mouse leukemia cells in vitro, as well as inhibiting l1210 murine leukemia cells grown in vivo. The mechanism for this inhibition is not yet known, but may be due to its ability to bind with hydrogen bonds or intramolecular hydrogen bonds. 3-Hydroxybenzamide also has a skeleton that can be synthesized asymmetrically by using a chiral

• Brand: Biosynth

Chemical properties

• Molecular weight: 137.14 g/mol
• Formula: C₇H₇NO₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C7H7NO2/c8-7(10)5-2-1-3-6(9)4-5/h1-4,9H,(H2,8,10)
• InChI key: InChIKey=NGMMGKYJUWYIIG-UHFFFAOYSA-N
• SMILES: NC(=O)c1cccc(O)c1