3a-Hydroxy-7-oxo-5b-cholanic acid

CAS: 4651-67-6

Ref. 3D-FH75036

Product Information

• Name: 3a-Hydroxy-7-oxo-5b-cholanic acid
• Synonyms: (S)-4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
• Brand: Biosynth
• Description: 3a-Hydroxy-7-oxo-5b-cholanic acid (3OHC) is a metabolite of 7-oxo-5b-cholanate, which is synthesized from cholic acid by the bacterial strain Clostridium species. 3OHC has been shown to be a potent inhibitor of human serum primary sclerosing cholangitis, which is an inflammatory disease of the bile ducts in the liver. It functions by inhibiting the formation of hydroxyl radicals, which are reactive oxygen species that cause tissue injury. The hydroxyl group in 3OHC reacts with the sulfhydryl groups on cysteine residues in proteins and forms sulfenic acids, which react with hydrogen peroxide to form chemically stable products. 3OHC also inhibits bacterial growth by binding to DNA and inhibiting transcription and replication.

Chemical properties

• Molecular weight: 390.56 g/mol
• Formula: C₂₄H₃₈O₄
• Purity: Min. 95%