Icaritin

CAS: 118525-40-9

Ref. 3D-FI24531

Product Information

• Name: Icaritin
• Synonyms: 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one, 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one, 4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-, 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-, 4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-, Af 40, Anhydroicaritin, Anhydroicaritin, β-, Cycloicaritin, Icaritin, b-anhydro-, b-Anhydroicaritin

Description

Icaritin is a natural compound that belongs to the class of flavonoids. It has been shown to inhibit apoptosis by blocking the mitochondrial pathway and suppressing caspase-3 activity in human cancer cells. Icaritin also inhibits the activity of protein kinases, leading to decreased expression of genes involved in energy metabolism and signal pathways. The molecular docking analysis showed that icaritin binds to the active site of polymerase chain reaction (PCR). Icaritin inhibits cell proliferation by binding to DNA, which prevents transcription and replication. Icaritin also has anti-inflammatory properties, as it can inhibit prostaglandin synthesis. Icaritin may be used for the treatment of inflammation-related diseases such as rheumatoid arthritis or Crohn's disease.

• Brand: Biosynth

Chemical properties

• Molecular weight: 368.38 g/mol
• Formula: C₂₁H₂₀O₆
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
• InChI key: InChIKey=TUUXBSASAQJECY-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2oc3c(CC=C(C)C)c(O)cc(O)c3c(=O)c2O)cc1