Indomethacin

CAS: 53-86-1

Ref. 3D-FI24585

Product Information

• Name: Indomethacin
• Synonyms: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acidIndometacin, 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid, 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid, 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid, 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid, 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid, 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid, Aconip, Amuno, Argun, Artracin, Artrinovo, Artrivia, Bonidin, Bonidon Gel, Catlep, Chibro-Amuno, Chrono-Indicid, Chrono-Indocid 75, Confortid, Dolcidium, Dolcidium PL, Dolovin, Durametacin, Elmetacin, Endol, Flam, Globa, Idomethine, Imbrilon, Inacid, Indacin, Indo-Phlogont, Indo-Rectolmin, Indo-Tablinen, IndoRich, Indocid, Indocid (pharmaceutical), Indocin, Indocine, Indocollyre, Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-, Indomecol, Indomed, Indomee, Indometacin, Indometacina, Indometacine, Indomethacin Crystalline, Indomethacin Methanol Solution, Indomethacin Powder, Indomethacin Usp, Indomethacine, Indomethine, Indomod, Indonol, Indoptic, Indoptol, Indorektal, Indoxen, Indren, Inflazon, Infrocin, Innamit, Inteban, Inteban SP, Lausit, Metacen, Metartril, Methazine, Metindol, Mezolin, Microcid, Mikametan, Mobilan, N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid, Nsc 77541, Reumacide, Rheumacin LA, Sadoreum, Tannex, Vital Vitacid, Vonum, [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid, {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate, α-[1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl]acetic acid

Description

Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.

• Brand: Biosynth

Chemical properties

• Molecular weight: 357.79 g/mol
• Formula: C₁₉H₁₆ClNO₄
• Purity: Min. 95%
• Color/Form: White Powder