Product Information
- 4-Iodo-1H-indole-2,3-dione
- 1H-Indole-2,3-dione, 4-iodo-
- Indole-2,3-dione, 4-iodo-
- Isatin, 4-iodo-
4-Iodoisatin is a heterocyclic compound that can be synthesized by cross-coupling reactions. It has been shown to inhibit the production of prostaglandin E2, COX-2 protein, and tumor necrosis factor in mouse macrophages. 4-Iodoisatin also inhibits the production of protein kinase C (PKC) in these cells. 4-Iodoisatin can be modified into a dimer form with many different substitutions on the ring structure and this modification increases its potency as an inhibitor of PKC. Irradiation can decompose the compound into a single isomer that is more potent than either of the two isomers. This drug may have therapeutic potential for treatment of cancer, arthritis, and other inflammatory disorders.
Chemical properties
Technical inquiry about: 3D-FI67680 4-Iodoisatin
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