Pseudolaric acid B

CAS: 82508-31-4

Ref. 3D-FI73857

Product Information

• Name: Pseudolaric acid B
• Synonyms: (2E,4E)-5-[(3R,4R,4aS,9aR)-4a,7-bis(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-4,9a-ethanocyclohepta[c]pyran-3(1H)-yl]-2-methylpenta-2,4-dienoic acid, (2E,4E)-5-[(4aS)-4a-(acetyloxy)-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-4,9a-ethanocyclohepta[c]pyran-3(1H)-yl]-2-methylpenta-2,4-dienoic acid, 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3-(4-carboxy-1,3-pentadienyl)-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-methyl ester, [3R-[3α(1E,3E),4α,4aα,9aα]]-, 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-methyl ester, (3R,4S,4aS,9aR)-, 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadienyl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-methyl ester, (3R,4S,4aS,9aR)-, NSC 615488, O-Acetylpseudolaric acid C, Pseudolarix acid B

Description

Pseudolaric acid B is a natural compound that belongs to the group of polyketides. It has been shown to induce apoptosis in HL-60 cells by binding to DNA and inducing cell death by nuclear fragmentation. Pseudolaric acid B also induces the release of pro-apoptotic proteins, such as endonuclease G, from the mitochondria into the cytosol. This protein then activates caspase-independent pathways, leading to cell death through body formation. In addition, pseudolaric acid B inhibits some enzyme activities and enhances others, which may lead to changes in signal pathways and the pathogenic mechanism of cancer.

• Brand: Biosynth

Chemical properties

• Molecular weight: 432.46 g/mol
• Formula: C₂₃H₂₈O₈
• Purity: Min. 98 Area-%
• Color/Form: White Powder