Lansiumarin C
CAS: 205115-75-9
Ref. 3D-FIA11575
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire |
Product Information
- 9-[[(2E,6S)-6-Hydroxy-3,7-dimethyl-2,7-octadien-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one
- 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(6-hydroxy-3,7-dimethyl-2,7-octadienyl)oxy]-, (E)-(+)-
- 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2E,6S)-6-hydroxy-3,7-dimethyl-2,7-octadien-1-yl]oxy]-
- 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2E)-6-hydroxy-3,7-dimethyl-2,7-octadienyl]oxy]-, (+)-
Lansiumarin C is a macrophage-active compound that belongs to the class of carbazole alkaloids. It has been shown to have potent inhibition of TNF-α production, with IC50 values in the range of 1.5 - 2.5 μM, which are comparable to those observed for clausenamide and imperatorin. Lansiumarin C has also been shown to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 cells, as well as IL1β and IL6 production in LPS-stimulated human peripheral blood mononuclear cells.
The skeleton of lansiumarin C is composed of two moieties: a carbazole ring and an aromatic ring with a nitrogen atom at the center of its structure. The two enantiomers are formed by the orientation of these moieties around the central nitrogen atom.
Chemical properties
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