Product Information
Bu 224 hydrochloride is an exogenous ligand that binds to the imidazoline I1 receptor. It is a potent and selective agonist for this receptor, which has been shown to be located in cardiac tissue. Bu 224 hydrochloride has been shown to increase the release of noradrenaline from cardiac cells, resulting in cardiostimulant effects. The binding of Bu 224 hydrochloride to the I1 receptor also increases blood pressure, heart rate, and myocardial contractility. The effect on blood pressure is dose-dependent: low doses result in a mild increase in blood pressure, whereas higher doses can lead to severe hypertension.
Bu 224 hydrochloride has been shown to have an effect on moxonidine-induced decreases in agmatine levels by increasing agmatine synthesis through the activation of imidazoline I1 receptor signalling cascades. It was found that buprenorphine had no effect on moxonidine
Chemical properties
Technical inquiry about: 3D-FIA43764 Bu 224 hydrochloride
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