Product Information
- 2-Hydroxy-4,5-difluorobenzoic acid
- 4,5-Difluorosalicylic acid
- Benzoic acid, 4,5-difluoro-2-hydroxy-
4,5-Difluoro-2-hydroxybenzoic acid is a fluorinated molecule that inhibits the enzyme dihydrofolate reductase. It is an efficient and selective inhibitor of mammalian folate metabolism and has been shown to be a potent inhibitor of tuberculosis in experimental animals. The drug binds to the magnesium ion and blocks the active site of dihydrofolate reductase, preventing it from reducing dihydrofolate to tetrahydrofolate. As a result, 4,5-difluoro-2-hydroxybenzoic acid inhibits bacterial growth by blocking the synthesis of DNA and RNA, which are necessary for protein synthesis and cell division. The drug has also been shown to be safe in humans with no adverse effects on kidney or liver function.
Chemical properties
Technical inquiry about: 3D-FIA53331 4,5-Difluoro-2-hydroxybenzoic acid
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