3-Keto petromyzonol

CAS: 359436-56-9

Ref. 3D-FK24780

Product Information

• Name: 3-Keto petromyzonol
• Synonyms: (5a,7a,12a)-7,12,24-Trihydroxy-cholan-3-one
• Brand: Biosynth
• Description: 3-Keto petromyzonol is a natural product that is biosynthesized in the liver from taurocholic acid. It has been shown to inhibit the synthesis of estradiol and progesterone in both rat and human tissue. 3-Keto petromyzonol has also been shown to have anti-obesity effects in mice, with decreased hepatic steatosis, as well as beneficial effects on insulin resistance and genes expression. The structural elucidation of 3-keto petromyzonol was accomplished by NMR spectroscopy, which revealed its disulfate structure. This chemical compound can be synthesized from methyl 2-(2′-chloroacetyl)malonate or from 1,4-dibromobutane. 3-Keto petromyzonol has been shown to inhibit ATP binding cassette transporter (ABC) proteins that are involved in cholesterol transport across the membrane. It may also act as a pheromone

Chemical properties

• Molecular weight: 392.57 g/mol
• Formula: C₂₄H₄₀O₄
• Purity: Min. 95%