Lactoferricin B25

CAS: 146897-68-9

Ref. 3D-FL110082

Product Information

• Name: Lactoferricin B25
• Synonyms: LFcinB 25, Lactoferricin B (17-41) (bovine)H-Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Ar g-Arg-Ala-Phe-OH trifluoroacetate salt (Disulfide bond), L-Phenylalanine, L-phenylalanyl-L-lysyl-L-cysteinyl-L-arginyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-tryptophyl-L-arginyl-L-methionyl-L-lysyl-L-lysyl-L-leucylglycyl-L-alanyl-L-prolyl-L-seryl-L-isoleucyl-L-threonyl-L-cysteinyl-L-valyl-L-arginyl-L-arginyl-L-alanyl-, Lactoferrin, Lfn B

Description

Lactoferricin B25 is a potent anticancer agent that has shown significant activity in vitro against cancer cell lines. It has been shown to induce apoptosis and autophagy, which are both methods of inducing cell death. Lactoferricin B25 also induces caspase-mediated apoptosis and has been shown to be effective in the treatment of cancer cells in vivo. Lactoferricin B25 binds with high affinity to the cell membrane, which is thought to be responsible for its anticancer activity. The half-maximal inhibitory concentration (IC50) for this compound is about 2 μM, with a concomitant cytotoxic effect at 10 μM. Lactoferricin B25 binds to DNA polymerase, preventing DNA replication and transcription. The binding of lactoferricin B25 to DNA polymerase inhibits the synthesis of RNA from DNA templates by inhibiting the elongation step of transcription.

• Brand: Biosynth

Chemical properties

• Molecular weight: 3,123.78 g/mol
• Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃
• Purity: Min. 90 Area-%
• Color/Form: Powder