Lumefantrine

CAS: 82186-77-4

Ref. 3D-FL24956

Product Information

• Name: Lumefantrine
• Synonyms: (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol, (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol, (Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol, 2-(dibutylamino)-1-{(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl}ethanol, 2-Dibutylamino-1-[2,7-dichloro-9-[1-(4-chlorophenyl)meth-(Z)-ylidene]-9H-fluoren-4-yl]ethanol, 9H-Fluorene-4-methanol, 2,7-dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-, (9Z)-, 9H-Fluorene-4-methanol, 2,7-dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-, (Z)-, Benflumelol, dl-Benflumelol

Description

Lumefantrine is a drug that belongs to the class of antimalarial drugs. It is used for the treatment of malaria caused by Plasmodium falciparum, and has been shown to be effective against chloroquine-resistant strains. Lumefantrine inhibits polymerase chain reaction by binding to the β subunit of DNA polymerase, thereby preventing mRNA transcription. The rate constant for lumefantrine was calculated using data from environmental stressors such as heat and cold, and from long-term toxicity studies in rats. Lumefantrine has also been shown to have cardiac effects through its ability to inhibit the activity of α1-acid glycoprotein. This drug inhibits p-glycoprotein (Pgp), which is an ATP-dependent efflux pump located on the cell membrane that pumps out drugs from cells. Pgp inhibitors are useful in combination with other chemotherapeutic agents, such as doxorubicin or vincristine

• Brand: Biosynth

Chemical properties

• Molecular weight: 528.94 g/mol
• Formula: C₃₀H₃₂Cl₃NO
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
• InChI key: InChIKey=DYLGFOYVTXJFJP-MYYYXRDXSA-N
• SMILES: CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1