Licochalcone A

CAS: 58749-22-7

Ref. 3D-FL46247

Product Information

• Name: Licochalcone A
• Synonyms: (2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one, (2E)-3-[5-(1,1-Dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one, (2E)-3-[5-(1,1-dimethylprop-2-en-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one, 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-, 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (E)-, 2-propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-, Licochalcone-A

Description

Licochalcone A is a natural compound that induces autophagy. It binds to the penicillin-binding protein (PBP) in the bacterial cell wall by competitive inhibition, inhibiting the production of proteins vital for cell division. Licochalcone A has been shown to be effective against infectious diseases, such as tuberculosis and leprosy. The concentration-time curve of licochalcone A was determined using electrochemical impedance spectroscopy on solid tumours in mice. This drug has also been shown to have an apoptosis-inducing effect on human osteosarcoma cells by preventing dna binding activity and blocking the pathway that leads to apoptosis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 338.4 g/mol
• Formula: C₂₁H₂₂O₄
• Purity: Min. 97 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
• InChI key: InChIKey=KAZSKMJFUPEHHW-DHZHZOJOSA-N
• SMILES: C=CC(C)(C)c1cc(/C=C/C(=O)c2ccc(O)cc2)c(OC)cc1O