Leptomycin B

CAS: 87081-35-4

Ref. 3D-FL75164

Product Information

• Name: Leptomycin B
• Brand: Biosynth
• Description: Leptomycin B is a bacterial secondary metabolite, which is derived from the bacterium Streptomyces sp. This compound is a potent nuclear export inhibitor with a mechanism of action that targets and inhibits the export receptor CRM1 (Chromosomal Maintenance 1), also known as Exportin 1. By binding irreversibly to CRM1, Leptomycin B prevents the nuclear export of proteins and RNA, disrupting the nuclear-cytoplasmic transport essential for cell function.

Chemical properties

• Molecular weight: 540.73 g/mol
• Formula: C₃₃H₄₈O₆
• Purity: Min. 95%