Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

Ref. 3D-FLS-1733-PI

Product Information

• Name: Fmoc-Ser(tBu)-OH
• Synonyms: (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid, (2S)-3-(tert-Butoxy)-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)propanoic acid, (2S)-3-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate, <span class="text-smallcaps">L</span>-Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, Fmoc-L-Ser(tBu)-OH, Fmoc-Ser(OtBu)-OH, N-(9-Fluorenylmethoxycarbonyl)-O-Tert-Butyl-L-Serine, N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine, N-Fmoc-O-tert-butyl-L-serine, O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-serine, O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)serine, O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine, O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]serine

Description

Fmoc-Ser(tBu)-OH is a synthetic peptide that is used in the synthesis of peptides and proteins. It is synthesized by using a stepwise procedure, which involves the use of morpholine as an organic base to deprotonate the carboxylic acid group and then reacting it with trifluoroacetic acid (TFA) to form the corresponding chloroformate ester. The amide bond is formed by reaction with ammonia or an amine. Finally, it can be reacted with hydrochloric acid to form the corresponding hydrochloride salt, which is insoluble in water. Impurities such as thionyl chloride and chloroformate can be removed by washing with methylene chloride or chloroform, respectively. Fmoc-Ser(tBu)-OH has been shown to be selective for the formation of hydrophobic bonds between amino acids and is not reactive toward other side chains on the protein.

• Brand: Biosynth

Chemical properties

• Molecular weight: 383.45 g/mol
• Formula: C₂₂H₂₅NO₅
• Purity: Min. 98.0 Area-%