2-Mercaptonicotinic acid

CAS: 38521-46-9

Ref. 3D-FM00951

Product Information

• Name: 2-Mercaptonicotinic acid
• Synonyms: 2-Mercaptopyridine-3-carboxylic acid, (2-thioxopyridin-3(2H)-ylidene)methanediolate, 1,2-Dihydro-2-thioxo-3-pyridinecarboxylic acid, 2-Mercapto-3-Pyridinecarboxylic Acid, 2-Mercapto-3-carboxypyridine, 2-Mercaptopyridine-3-Carboxylic Acid, 2-Sulfanylidene-1H-pyridine-3-carboxylic acid, 2-Sulfanylnicotinic Acid, 2-Sulfanylpyridine-3-Carboxylic Acid, 2-Thionicotinic Acid, 2-Thioxo-1,2-Dihydropyridine-3-Carboxylate, 2-Thioxo-1,2-dihydro-pyridine-3-carboxylic acid, 3-Aza-2-thiosalicylic acid, 3-Pyridinecarboxylic acid, 1,2-dihydro-2-thioxo-, Labotest-Bb Lt01596005

Description

2-Mercaptonicotinic acid (2MNA) is an inhibitor of the P-glycoprotein, which is a multidrug resistance-associated protein. It prevents the transport of drugs and other molecules across the cell membrane. 2MNA has been shown to inhibit cancer cells in cervical cancer studies, and has been proven to reduce the toxicity of chemotherapy drugs in rats. 2MNA binds to p-glycoprotein and inhibits its function by forming a disulfide bond with cysteine residues on the transporter. 2MNA also has toxic effects on human serum and may be hazardous for use as a therapeutic agent.

• Brand: Biosynth

Chemical properties

• Molecular weight: 155.18 g/mol
• Formula: C₆H₅NO₂S
• Purity: Min. 95%