Product Information
- 2-Thiopurine2-Purinethiol
- 1,3-Dihydro-2H-purine-2-thione
- 1H-Purine-2-thiol
- 2-Thiopurine
- 2H-Purine-2-thione, 1,3-dihydro-
- 2H-Purine-2-thione, 1,3-dihydro- (9CI)
- 2H-Purine-2-thione, 3,9-dihydro-
- 3,5-dihydro-2H-purine-2-thione
- 3,7-dihydro-2H-purine-2-thione
- 5-Mercaptopurine
- See more synonyms
- Nsc 23720
- Purine-2(3H)-thione
- Purine-2-thiol
- Purine-2-thione
- 3,9-Dihydro-2H-purine-2-thione
2-Mercaptopurine (2MP) is a thiopurine drug that is used to treat bowel disease. 2MP inhibits the activity of methyltransferase, which is an enzyme that converts 6-mercaptopurine to 6-thioguanine. This process prevents the conversion of 6-thioguanine into 6-thiouric acid, which is an intermediate in the synthesis of thymine nucleotides. 2MP also inhibits the binding of atp-binding cassette transporter proteins to DNA and blocks the incorporation of purines into RNA and DNA. The drug has been shown to be effective in treating squamous cell carcinoma and other diseases with a high level of activity. 2MP has been shown to be metabolized by erythrocyte polymerase chain reaction and can be detected in biological samples.
Chemical properties
Technical inquiry about: 3D-FM02961 2-Mercaptopurine
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