2-Mercaptopyridine

CAS: 2637-34-5

Ref. 3D-FM07088

Product Information

• Name: 2-Mercaptopyridine
• Synonyms: Thio-2-pyridine2-Thiopyridine, 1,2-Dihydropyridine-2-thione, 1H-Pyridine-2-thione, 2-Pyridinethiol, 2-Pyridinethione, 2-Pyridothione, 2-Pyridyl mercaptan, 2-Pyridylthiol, 2-Sulfanylpyridine, 2-Thiopyridine, 2-Thiopyridone, Alrithiol-2, Nsc 41337, Piridina-2-Tiol, Pyridin-2-thiol, Pyridine-2-thiol, Wr 608

Description

2-Mercaptopyridine is a quinone that has been used as an inhibitor of the HIV reverse transcriptase enzyme. It binds to the active site of the enzyme and inhibits its activity by forming a stable covalent bond with two cysteine residues in the enzyme. The molecule is stabilized by two adjacent sulfide bonds, which form a six-membered ring with three nitrogen atoms and one oxygen atom. This ring coordinates to the zinc ion in the active site of the enzyme. 2-Mercaptopyridine has also been found to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis.
2-Mercaptopyridine binds to DNA at positions where it is complementary to guanine or adenine nucleotides, thus preventing RNA synthesis and replication.

• Brand: Biosynth

Chemical properties

• Molecular weight: 111.17 g/mol
• Formula: C₅H₅NS
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C5H5NS/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)
• InChI key: InChIKey=WHMDPDGBKYUEMW-UHFFFAOYSA-N
• SMILES: S=c1cccc[nH]1