6-Mercaptopurine hydrate

CAS: 6112-76-1

Ref. 3D-FM08197

Product Information

• Name: 6-Mercaptopurine hydrate
• Synonyms: 6-Thiohypoxanthine6-Purinethiol monohydrate, 1,4,5,7-Tetrahydro-6H-Purine-6-Thione Hydrate, 1,7-Dihydro-6H-Purin-6-Thion,Monohydrat, 1,7-Dihydro-6H-Purine-6-Thionemonohydrate, 1,7-Dihydro-6H-Purine-6-Thionmonohydrate, 3,7-Dihydro-6H-Purine-6-Thione Hydrate, 6-Mercapto Purine, 6-Mercaptopurine Hydrate, 6-Merkaptopurin,Monohydrat, 6-Purinethiol Monohydrate, 6-Thiohypoxanthine Monohydrate, 6H-Purin-6-Thion,Monohydrat, 6H-Purine-6-thione, 1,2,3,9-tetrahydro-, hydrate (1:1), 6H-Purine-6-thione, 1,7-dihydro-, monohydrate, 7H-Purine-6-Thiolate, 9H-Purine-6-thiol hydrate, Leukerin Monohydrate, Mercaleukin Monohydrate, Mercaptopurine Monohydrate, 6-Mercaptopurine, Mercaptopurine, Monohydrate, Purin-6-Thiol,Monohydrat, Purine-6-Thiol, Monohydrate, Xaluprine
• CAS: 6112-76-1

Description

6-Mercaptopurine is a purine analog that suppresses the production of white blood cells by inhibiting the enzyme thiopurine methyltransferase. It has been used to treat bowel disease and also for long-term suppression of the immune system in patients with autoimmune diseases. 6-Mercaptopurine is metabolized to 6-mercaptopurine, which is then converted to dinucleotide phosphate (dNTP) by group P2 enzymes. This conversion allows 6-mercaptopurine to inhibit dNTP synthesis and cell division. The effects of 6-mercaptopurine are potentiated when given in conjunction with azathioprine, another drug that inhibits purine metabolism. 6-Mercaptopurine is not active against human serum albumin or erythrocytes because it cannot be cleaved into an active form by these proteins. However, it does inhibit enzyme activities such as DNA polymerase, RNA polymerase, and protein

• Brand: Biosynth

Chemical properties

• Molecular weight: 152.18 g/mol
• Formula: C₅H₄N₄S•H₂O
• Purity: Min. 97 Area-%
• Color/Form: Yellow Powder