1-Methyl-1H-indole-3-carbohydrazide

CAS: 56559-62-7

Ref. 3D-FM114293

Product Information

• Name: 1-Methyl-1H-indole-3-carbohydrazide
• Brand: Biosynth
• Description: 1-Methyl-1H-indole-3-carbohydrazide (MZ) is a potential anticancer drug that inhibits the growth of cancer cells. It binds to the colchicine binding site on the DNA, which prevents doxorubicin from binding and causing damage to the DNA. MZ has been shown to be effective against breast cancer and has been shown to inhibit tumor growth in mice by targeting cancer cells lines. MZ also inhibits proliferation of MDA-MB-231 cells in culture, as well as inhibiting cell cycle progression, leading to apoptosis. The molecular docking studies show that 1MZ binds to colchicine site on DNA with high affinity and specificity.

Chemical properties

• Molecular weight: 189.21 g/mol
• Formula: C₁₀H₁₁N₃O
• Purity: Min. 95%
• InChI: InChI=1S/C10H11N3O/c1-13-6-8(10(14)12-11)7-4-2-3-5-9(7)13/h2-6H,11H2,1H3,(H,12,14)
• InChI key: InChIKey=KMYZDVOJRUTMEA-UHFFFAOYSA-N
• SMILES: Cn1cc(C(=O)NN)c2ccccc21