6-Mercapto-9H-purin-2-ol

CAS: 2002-59-7

Ref. 3D-FM154145

Product Information

• Name: 6-Mercapto-9H-purin-2-ol
• Synonyms: 1,3,6,9-Tetrahydro-6-thioxo-2H-purin-2-one, 2-Hydroxy-6,7-dihydro-1H-purine-6-thione, 2-Hydroxy-6-mercaptopurine, 2-Hydroxy-6-thiopurine, 2H-Purin-2-one, 1,3,6,7-tetrahydro-6-thioxo-, 2H-Purin-2-one, 1,3,6,9-tetrahydro-6-thioxo-, 3,6-Dihydro-6-thioxo-9H-purine-2(1H)-one, 6-Mercaptoxanthine, 6-thioxo-1,3,5,6-tetrahydro-2H-purin-2-one, 6-thioxo-1,3,6,7-tetrahydro-2H-purin-2-one, 6-thioxo-6,7-dihydro-3H-purin-2-olate, Ai3-52244, Nsc 12160, Thioxanthine, Xanthine, 6-thio-

Description

6-Mercapto-9H-purin-2-ol (6MP) is a purine nucleoside that is used as an antimicrobial agent. It inhibits the enzyme adenosine deaminase, which converts adenosine to inosine, and therefore prevents the production of purines. 6MP has been shown to be effective against inflammatory bowel disease and bowel disease in animal models. At high concentrations, it has been shown to inhibit subcutaneous tumors in mice. 6MP also inhibits the metabolism of certain drugs such as rifampicin and phenytoin, thereby increasing their plasma concentration. 6MP has been shown to be effective against resistant mutants for some bacteria such as Salmonella enterica serovar Typhimurium and Escherichia coli through inhibition of beta-lactamases. The mechanism of action for 6MP is similar to that of β-lactams antibiotics, which are inhibitors of bacterial cell wall synthesis

• Brand: Biosynth

Chemical properties

• Molecular weight: 168.18 g/mol
• Formula: C₅H₄N₄OS
• Purity: Min. 95%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C5H4N4OS/c10-5-8-3-2(4(11)9-5)6-1-7-3/h1H,(H3,6,7,8,9,10,11)
• InChI key: InChIKey=RJOXFJDOUQJOMQ-UHFFFAOYSA-N
• SMILES: O=c1[nH]c(=S)c2[nH]cnc2[nH]1