2-Methyl-4(3H)-quinazolinone

CAS: 1769-24-0

Ref. 3D-FM171915

Product Information

• Name: 2-Methyl-4(3H)-quinazolinone
• Synonyms: 2-Methyl-3,4-dihydroquinazolin-4-one, 2-Methyl-3H-quinazolin-4-one, 2-Methyl-4(3H)-quinazolone, 2-Methyl-4-oxoquinazoline, 2-Methyl-4-quinazolinol, 2-Methyl-4-quinazolinone, 2-Methyl-4-quinazolone, 2-Methyl-chinazolinone(4), 2-Methyl-chinazolinone(4) [German], 2-Methylquinazolin-4(1H)-one, 2-Methylquinazolone, 3H-2-Methyl-4-oxoquinazoline, 4(1H)-Quinazolinone, 2-methyl-, 4(1H)-Quinazolinone, 2-methyl- (7CI,9CI), 4(3H)-Quinazolinone, 2-methyl-, 4-Hydroxy-2-methylquinazoline, 4-Quinazolinol, 2-methyl-, 4-Quinazolinol, 2-methyl- (8CI), Ai3-52030, Aurora Ka-3754, B 101, Nsc 12005, Nsc 2757

Description

2-Methyl-4(3H)-quinazolinone is a quinazolinone that has been found to be an inhibitor of tumor necrosis factor-α (TNF-α) production. This compound also has strong antibacterial activity against Staphylococcus aureus and Bacillus subtilis. 2-Methyl-4(3H)-quinazolinone inhibits bacterial growth by binding to DNA dependent RNA polymerase, preventing transcription and replication. The high frequency of human activity has been shown using a patch clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 2-Methyl-4(3H)-quinazolinone also specifically binds to markers expressed at high levels in

• Brand: Biosynth

Chemical properties

• Molecular weight: 160.17 g/mol
• Formula: C₉H₈N₂O
• Purity: Min. 95%
• Color/Form: Powder