(R)-Monophos

Ref. 3D-FM180381

Product Information

• Name: (R)-Monophos
• Brand: Biosynth
• Description: (R)-Monophos is an antitumor agent that inhibits the growth of cancer cells. It is a potent inhibitor of DNA synthesis, which is essential for cell division. (R)-Monophos has been shown to be effective against a number of cancer cell lines, including leukemia, lymphoma and breast cancer cells. This drug is synthesized by the cross-coupling reaction between a phosphine and an activated carbonyl group. The mechanism of this reaction involves the formation of an iminium ion intermediate with phosphite as the leaving group. The iminium ion reacts with a chloroformate to produce (R)-monophos and hydrogen chloride as byproducts. Crystal x-ray diffraction data have provided evidence for this mechanism.

Chemical properties

• Molecular weight: 359.4 g/mol
• Formula: C₂₂H₁₈NO₂P
• Purity: Min. 95%