2-Methoxy 17b-estradiol

CAS: 362-07-2

Ref. 3D-FM25168

Product Information

• Name: 2-Methoxy 17b-estradiol
• Synonyms: (17b)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol2-Hydroxyestradiol 2-methyl ether2-Methoxyestra-1,3,5(10)-triene-3,17b-diol, (17Beta)-2-Methoxyestra-1(10),2,4-Triene-3,17-Diol, (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol, (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol, (9Xi,14Xi,17Beta)-2-Methoxyestra-1(10),2,4-Triene-3,17-Diol, 2-Hydroxyestradiol 2-methyl ether, 2-Hydroxyestradol 2-methyl ether, 2-Methoxy-E2, 2-Methoxyestra-1(10),2,4-Triene-3,17-Diol, 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol, 2-Methoxyestra-1,3,5(10)-triene-3,17β-diol, 2-Methoxyestradiol-17beta, 2Me2, Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17beta)-, Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)-, Estra-1,3,5(10)-triene-3,17beta-diol, 2-methoxy-, Estra-1,3,5(10)-triene-3,17β-diol, 2-methoxy-, Estradiol, 2-methoxy-, Nsc 659853, Panzem, Unii-6I2Qw73Sr5

Description

2-Methoxy 17b-estradiol is a synthetic estrogen that binds to DNA and alters the transcriptional process. It has been shown to induce apoptosis by activating the pro-apoptotic protein Bax and inhibiting the anti-apoptotic protein Bcl-2. This drug inhibits the metabolic response of cancer cells to chemotherapy, leading to a decrease in tumor size, and can be used as an implantable device for treating cancer. 2-Methoxy 17b-estradiol also has minimal toxicity in comparison to other estrogens, with no significant cytotoxicity observed in cells of reproductive tissues or endocrine organs, nor any significant toxic effects on liver function tests or serum lipids.

• Brand: Biosynth

Chemical properties

• Molecular weight: 302.41 g/mol
• Formula: C₁₉H₂₆O₃
• Purity: Min. 95%
• Color/Form: White/Off-White Solid
• InChI: InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
• InChI key: InChIKey=CQOQDQWUFQDJMK-SSTWWWIQSA-N
• SMILES: COc1cc2c(cc1O)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12