N10-Methyl pteroic acid

CAS: 5623-18-7

Ref. 3D-FM25554

Product Information

• Name: N10-Methyl pteroic acid
• Synonyms: 4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoic acidp-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]b enzoic acidMetfol-B, 4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoic acid, Benzoic Acid, 4-[[(2-Amino-1,4-Dihydro-4-Oxo-6-Pteridinyl)Methyl]Methylamino]-, Benzoic acid, 4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]-, Benzoic acid, p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]-, Metfol-B, NSC 408937

Description

N10-Methyl pteroic acid is a novel immunosuppressant that inhibits T-cell proliferation and promotes regression of inflammatory bowel disease. It has been shown to be effective in treating cancer patients, with the terminal half-life being approximately 20 hours. N10-Methyl pteroic acid is a potent inhibitor of human acute lymphoblastic leukemia cells. It can also be used as an immunosuppressant for organ transplantation, with desorption from gels using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) and bioanalytical methods such as high performance liquid chromatography (HPLC).

• Brand: Biosynth

Chemical properties

• Molecular weight: 326.31 g/mol
• Formula: C₁₅H₁₄N₆O₃
• Purity: Min. 95%
• InChI: InChI=1S/C15H14N6O3/c1-21(10-4-2-8(3-5-10)14(23)24)7-9-6-17-12-11(18-9)13(22)20-15(16)19-12/h2-6H,7H2,1H3,(H,23,24)(H3,16,17,19,20,22)
• InChI key: InChIKey=QHNLFEQJGRZKTK-UHFFFAOYSA-N
• SMILES: CN(Cc1cnc2nc(N)[nH]c(=O)c2n1)c1ccc(C(=O)O)cc1