3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline

CAS: 641571-11-1

Ref. 3D-FM25612

Product Information

• Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline
• Synonyms: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole
• Brand: Biosynth
• Description: 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline (MTIA) is a diazotization agent that is used in the industrial production of nilotinib, an anti-cancer drug. MTIA reacts with ethyl acetate to form ethyl 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, which can then be reacted with hydrochloric acid to produce MTIA hydrochloride. The MTIA hydrochloride can be dissolved in water and used as a diazotization agent. The sequence of these reactions is: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline + ethyl acetate → ethyl 3-(4-methyl--1H--

Chemical properties

• Molecular weight: 241.21 g/mol
• Formula: C₁₁H₁₀F₃N₃
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
• InChI key: InChIKey=WWTGXYAJVXKEKL-UHFFFAOYSA-N
• SMILES: Cc1cn(-c2cc(N)cc(C(F)(F)F)c2)cn1