4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

CAS: 76014-81-8

Ref. 3D-FM25896

Product Information

• Name: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
• Synonyms: a-[3-(Methylnitrosoamino)propyl]-3-pyridinemethanolracNNAL4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)butan-1-ol, (±)-Nnal, 3-Pyridinemethanol, Alpha-[3-(Methylnitrosoamino)Propyl]-, 3-Pyridinemethanol, α-[3-(methylnitrosoamino)propyl]-, 4-(Methylnitrosoamino)-1--(3-Pyridyl)-1-Butanol, 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)butan-1-ol, 4-[Methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanol, 76014-81-8, Racemic 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, Racemic NNAL, α-[3-(Methylnitrosoamino)propyl]-3-pyridinemethanol

Description

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of nicotine that has been shown to be carcinogenic in vivo. It binds to DNA, forming adducts with guanine, and can cause mutations and chromosomal aberrations. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is excreted in urine as a glucuronide conjugate. Its potential use as a biomarker for tobacco smoking has been demonstrated by the observation of increased levels following exposure to cigarette smoke. The urinary concentration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol has been correlated with the risk for lung cancer in humans, and it may be useful as an analytical method for determining tobacco consumption.

• Brand: Biosynth

Chemical properties

• Molecular weight: 209.25 g/mol
• Formula: C₁₀H₁₅N₃O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C10H15N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8,10,14H,3,5,7H2,1H3
• InChI key: InChIKey=OGRXKBUCZFFSTL-UHFFFAOYSA-N
• SMILES: CN(CCCC(O)c1cccnc1)N=O