cis-Montelukast

CAS: 774538-96-4

Ref. 3D-FM26070

Product Information

• Name: cis-Montelukast
• Synonyms: 1-[[[(1R)-1-[3-[(1Z)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hy droxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid
• Brand: Biosynth
• Description: Montelukast is a beta-adrenergic receptor antagonist that blocks the binding of leukotrienes to their receptors, resulting in decreased airway inflammation and obstruction. It is used for the prevention and treatment of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. The efficiency of this drug has been shown in experiments with nifedipine, which is a calcium channel blocker. Montelukast is sensitive to light, which may change its structure. This drug also binds to clavulanic acid, an inhibitor of beta-lactamase enzymes found in some bacteria. This interaction prevents the breakdown of clavulanic acid by these enzymes and increases its antibacterial activity. Montelukast can be quantified using UV absorption spectroscopy or HPLC methods. These methods are more specific than UV spectroscopy because they can measure both cis-montelukast and trans-montelukast equally well.

Chemical properties

• Molecular weight: 586.18 g/mol
• Formula: C₃₅H₃₆ClNO₃S
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10-/t32-/m0/s1
• InChI key: InChIKey=UCHDWCPVSPXUMX-KZIOJDGPSA-N
• SMILES: CC(C)(O)c1ccccc1CC[C@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C\c2ccc3ccc(Cl)cc3n2)c1