Methyl-4-iodobenzoate

CAS: 619-44-3

Ref. 3D-FM30437

Product Information

• Name: Methyl-4-iodobenzoate
• Brand: Biosynth

Description

Methyl-4-iodobenzoate is an organic compound that can be used as a precursor to the synthesis of pemetrexed, a drug that has been shown to be effective against cancer. Methyl-4-iodobenzoate is synthesized by combining 4-iodobenzoic acid with methyl iodide in the presence of sodium azide. The reaction mechanism is thought to involve the formation of an aziridine intermediate and proceeds via a suzuki coupling reaction. This compound can also be synthesized through hydrolysis of methyltriazole and azetidinium chloride with potassium hydroxide, followed by chlorination with hydrochloric acid. Methyl-4-iodobenzoate is soluble in organic solvents such as chloroform and ether, but not in water.

Chemical properties

• Molecular weight: 262.04 g/mol
• Formula: C₈H₇IO₂
• Purity: Min. 95%
• Color/Form: Powder