2-Methoxy promazine

CAS: 61-01-8

Ref. 3D-FM34072

Product Information

• Name: 2-Methoxy promazine
• Synonyms: 10-(3-Dimethylaminopropyl)-2-methoxyphenothiazine, 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N-dimethyl-, 2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine, 2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine, 2-Methoxypromazine, 3-(2-methoxy-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, 4632Rp, Methopromazinum, Methopromazinum [INN-Latin], Methoxypromazine, Metopromazina, Metopromazina [INN-Spanish], Neoproma, Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy, Rp 4632, Tenton, Tentone

Description

2-Methoxy promazine is a phenothiazine antipsychotic drug which has been used to treat chronic schizophrenia. It binds to the D2 receptor, and it is one of the most potent antipsychotic drugs for this receptor. 2-Methoxy promazine also binds to dopamine receptors, with a binding constant of 0.1 nM. 2-Methoxy promazine may be useful in the treatment of bowel disease because it has been shown to decrease bowel motility and increase colonic tone. 2-Methoxy promazine is not metabolized by cytochrome P450 enzymes, but it does have photochemical properties that can cause skin damage when exposed to sunlight. It is also an analog of promethazine, which belongs to the class of phenothiazine drugs. Promethazine is synthesized from 2-methylaminophenol and methylamine through a series of transfer reactions and hydrogen bonding.

• Brand: Biosynth

Chemical properties

• Molecular weight: 314.45 g/mol
• Formula: C₁₈H₂₂N₂OS
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C18H22N2OS/c1-19(2)11-6-12-20-15-7-4-5-8-17(15)22-18-10-9-14(21-3)13-16(18)20/h4-5,7-10,13H,6,11-12H2,1-3H3
• InChI key: InChIKey=BRABPYPSZVCCLR-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2