Methyl 6-chloronicotinate

CAS: 73781-91-6

Ref. 3D-FM36752

Product Information

• Name: Methyl 6-chloronicotinate
• Synonyms: 6-Chloronicotinic acid methyl ester, Methyl 6-chloropyridine-3-carboxylate, 3-Pyridinecarboxylic acid, 6-chloro-, methyl ester

Description

Methyl 6-chloronicotinate is a quinoline derivative that has been shown to have cytotoxic effects. This compound inhibits the DNA repair protein O6-alkylguanine-DNA alkyltransferase (O6-AGAT) and induces apoptosis by binding to the cation channel and inhibiting the influx of calcium ions, which leads to an increase in intracellular calcium levels. Methyl 6-chloronicotinate also inhibits cancer cell proliferation through its interaction with the voltage-gated sodium channels and potassium channels, which leads to cell death. The molecular modeling study revealed that methyl 6-chloronicotinate binds to a deep hydrophobic pocket on the surface of hct116 cells, indicating that this drug may be a potential anticancer agent.

• Brand: Biosynth

Chemical properties

• Molecular weight: 171.58 g/mol
• Formula: C₇H₆ClNO₂
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C7H6ClNO2/c1-11-7(10)5-2-3-6(8)9-4-5/h2-4H,1H3
• InChI key: InChIKey=RMEDXVIWDFLGES-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc(Cl)nc1