5-Methylisoxazole-3-carboxylic acid

CAS: 3405-77-4

Ref. 3D-FM57129

Product Information

• Name: 5-Methylisoxazole-3-carboxylic acid
• Synonyms: 3-Carboxy-5-methylisoxazole, 3-Isoxazolecarboxylic acid, 5-methyl-, 5-Methyl-1,2-Oxazole-3-Carboxylic Acid, 5-Methyl-3-isoxazolecarboxylic acid

Description

5-Methylisoxazole-3-carboxylic acid (5MI3CA) is a covalent inhibitor that binds to ATP synthase and blocks the synthesis of ATP. It has been shown to be an anti-viral agent with a broad spectrum of activity against HIV, herpes simplex virus, and vaccinia virus. 5MI3CA also has pharmacokinetic properties that are similar to those of other drugs in the same class, such as pyridoxal phosphate. This drug has been shown to inhibit the production of water molecules from glucose by human liver cells and it is stable when complexed with proteins.
5MI3CA is synthesized on a solid phase using a three step process involving acid hydrolysis, coupling reaction, and protection steps. The reaction mixture consists of methanesulfonic acid (MSA), DMAP, NMM, EDC/NHS ester, and 5MI3CA. The final product is

• Brand: Biosynth

Chemical properties

• Molecular weight: 127.1 g/mol
• Formula: C₅H₅NO₃
• Purity: Min. 95%
• InChI: InChI=1S/C5H5NO3/c1-3-2-4(5(7)8)6-9-3/h2H,1H3,(H,7,8)
• InChI key: InChIKey=BNMPIJWVMVNSRD-UHFFFAOYSA-N
• SMILES: Cc1cc(C(=O)O)no1