Nipecotic acid

CAS: 498-95-3

Ref. 3D-FN02349

Product Information

• Name: Nipecotic acid
• Synonyms: (±)-β-Homoproline, 3-Carboxypiperidine, 3-Piperidinecarboxylic acid, <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Nipecotic acid, DL-Nipecotic acid, H-DL-Nip-OH~(+/-)-Piperidine-3-carboxylic acid, Hexahydronicotinic acid, Piperidin-3-carboxylic acid, Piperidine-3-Carboxylic Acid
• CAS: 498-95-3

Description

Nipecotic acid is a competitive inhibitor of glutamate. It binds to the extracellular site of the glutamate-gated chloride channel and blocks the influx of chloride ions into the cell, resulting in an increase in intracellular chloride ion concentrations. Nipecotic acid has been shown to have a variety of effects on behaviour, including increased rotarod performance and improved motor learning in rats. This drug also inhibits uptake of hydrogen tartrate into cells, which is essential for catabolism of glucose by glycolysis. The effect on locomotor activity was not observed when nipecotic acid was administered orally or intraperitoneally. Nipecotic acid has a high resistance to hydrolysis by p-hydroxybenzoic acid and is used as an analytical standard for this compound.

• Brand: Biosynth

Chemical properties

• Molecular weight: 129.15 g/mol
• Formula: C₆H₁₁NO₂
• Color/Form: Powder
• InChI: InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)
• InChI key: InChIKey=XJLSEXAGTJCILF-UHFFFAOYSA-N
• SMILES: O=C(O)C1CCCNC1