Necrostatin-1 5-(1

CAS: 4311-88-0

Ref. 3D-FN111188

Product Information

• Name: Necrostatin-1 5-(1
• Synonyms: H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
• Brand: Biosynth
• Description: Necrostatin-1 is a small molecule inhibitor that blocks the NF-κB signaling pathway. Necrostatin-1 is a potent inducer of apoptosis and has been shown to inhibit necroptosis in cell culture. It also blocks the Toll-like receptor 4 (TLR4), which is an important death receptor that causes inflammation. Necrostatin-1 has been found to be effective in reducing injury and death in low doses, but has not been tested for long periods of time or at high doses.

Chemical properties

• Molecular weight: 259.33 g/mol
• Formula: C₁₃H₁₃N₃OS
• Purity: Min. 95%
• InChI: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
• InChI key: InChIKey=TXUWMXQFNYDOEZ-UHFFFAOYSA-N
• SMILES: CN1C(=O)C(Cc2c[nH]c3ccccc23)NC1=S